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Muscular hypertrophy refers specifically to the enlargement of muscle fibers, which results from resistance training or other forms of strength training. When muscles are subjected to stress, such as lifting weights or performing resistance exercises, the muscle fibers undergo micro-tears. The subsequent repair process involves the synthesis of new muscle proteins, leading to an increase in the size and cross-sectional area of the muscle fibers. Over time, this process enhances overall muscle strength and mass.

This concept is distinct from increasing muscle endurance, which focuses on the muscle's ability to perform repeated contractions over time rather than their size. Whereas muscular hypertrophy targets fiber enlargement, muscle endurance training emphasizes stamina and resistance to fatigue. Additionally, muscular hypertrophy does not imply a decrease in muscle mass; rather, it signifies a growth response. The reduction of fat around muscles is related to body composition changes, which, while possibly linked to strength training, is not synonymous with hypertrophy. Thus, the accurate definition aligns with the enlargement of muscle fibers.

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